mGluR1 (D5H10) Rabbit Monoclonal Antibody#12551,Cell Signaling Technology (CST),12551

Metabotropic glutamate receptor 1 (mGluR1) is a G protein-coupled receptor (GPCR) for the neurotransmitter glutamate in the mammalian brain. Unlike ionotropic receptors, metabotropic receptors do not form an ion channel pore themselves but are indirectly linked to ion channels (1). Both mGluR1 and mGluR5 are coupled to phospholipase C and activate inositol phospholipid metabolism via G protein-mediated mechanisms. Upon phosphatidylinositol activation, the second messenger calcium is released and generates a calcium-activated chloride current. Metabotropic glutamate receptors other than mGluR1 and mGluR5 inhibit adenylate cyclase (1-3). mGluR1 does not share sequence homology with conventional GPCRs (1). mGluR1 forms a homodimer and is linked to synaptic plasticity, as well as long-term potentiation and long-term depression. Furthermore, mGluR1 is a potential therapeutic target for various psychiatric and neurological diseases, including schizophrenia, epilepsy, and Parkinson and Alzheimer diseases (4-6).Pin, J.P. et al. (1994)EMBO J13, 342-8.Sugiyama, H. et al. (1987)Nature325, 531-3.Hermans, E. and Challiss, R.A. (2001)Biochem J359, 465-84.Niswender, C.M. et al. (2005)Curr Top Med Chem5, 847-57.Pellicciari, R. and Costantino, G. (1999)Curr Opin Chem Biol3, 433-40.Olive, M.F. (2009)Curr Drug Abuse Rev2, 83-989.Alternate Namesglutamate metabotropic receptor 1; glutamate receptor, metabotropic 1; GPRC1A; GRM1; GRM1A; Metabotropic glutamate receptor 1; mGlu1; MGLUR1; MGLUR1A; PPP1R85; protein phosphatase 1, regulatory subunit 85; SCA44; SCAR13

glutamate metabotropic receptor 1; glutamate receptor, metabotropic 1; GPRC1A; GRM1; GRM1A; Metabotropic glutamate receptor 1; mGlu1; MGLUR1; MGLUR1A; PPP1R85; protein phosphatase 1, regulatory subunit 85; SCA44; SCAR13