p16 INK4A (F2T7H) Rabbit Monoclonal Antibody (Alexa Fluor®488 Conjugate)#38083,Cell Signaling Technology (CST),38083

p16 INK4A (F2T7H) Rabbit Monoclonal Antibody (Alexa Fluor®488 Conjugate) recognizes endogenous levels of total p16 INK4A protein. This antibody does not cross-react with p15 INK4B protein. Non-specific cytoplasmic staining was observed in mouse small intestine epithelium by immunohistochemistry.

Host

Rabbit

Reactivity

Mouse

Application

Immunohistochemistry (Paraffin): 1:50 - 1:200 Flow Cytometry (Fixed/Permeabilized): 1:800

Platform ID

BAB950945380

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Namep16 INK4A (F2T7H) Rabbit Monoclonal Antibody (Alexa Fluor®488 Conjugate)#38083
Cat. No.38083
Accession NumberP51480
Gene ID (Entrez)51480, 12578
HostRabbit
SensitivityEndogenous
ReactivityMouse
ApplicationImmunohistochemistry (Paraffin): 1:50 - 1:200 Flow Cytometry (Fixed/Permeabilized): 1:800
ImmunogenIgG
FormulationSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C.Do not aliquot the antibody. Protect from light. Do not freeze.
StorageSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C.Do not aliquot the antibody. Protect from light. Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Members of the INK4 family of cyclin-dependent kinase inhibitors include p16 INK4A, p15 INK4B, p18 INK4C, and p19 INK4D. The INK4 family members inhibit cyclin-dependent kinases 4 and 6 (CDK4 and CDK6), causing cell cycle arrest in G1 phase. The INK4A-ARF-INK4B locus on chromosome 9p21, frequently lost in human cancer, encodes the INK4 family members p16 INK5A and p15 INK4B, as well as the unrelated protein, ARF (1).p16 INK4A expression, typically repressed in the absence of stress, is thought to drive cells into senescence, and p16 INK4A expression is a commonly used marker of senescent cells (2,3). p16 INK4A protein expression is often altered in human cancer, and high expression is currently used as a predictive biomarker in cervical cancer (3-5).Kim, W.Y. and Sharpless, N.E. (2006)Cell127, 265-75.LaPak, K.M. and Burd, C.E. (2014)Mol Cancer Res12, 167-83.Romagosa, C. et al. (2011)Oncogene30, 2087-97.Ishikawa, M. et al. (2006)Int J Gynecol Cancer16, 347-53.Queiroz, C. et al. (2006)Pathol Res Pract202, 77-83.Alternate Namesalternative reading frame; Arf; ARF-; ARF-INK4a; CD2A1; CDK4I; Cdkn2a; CDN2A; cyclin dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A, isoform 3; Cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; INK4; INK4a-ARF; Ink4a/Arf; mitochondrial smARF; MTS; MTS1; OTTMUSP00000008143; p16; p16-INK4; p16-INK4a; p16(INK4a); p16I; P16ink4a; p19; p19; p19ARF; Pct; Pctr1

Synonyms

alternative reading frame; Arf; ARF-; ARF-INK4a; CD2A1; CDK4I; Cdkn2a; CDN2A; cyclin dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A, isoform 3; Cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; INK4; INK4a-ARF; Ink4a/Arf; mitochondrial smARF; MTS; MTS1; OTTMUSP00000008143; p16; p16-INK4; p16-INK4a; p16(INK4a); p16I; P16ink4a; p19; p19; p19ARF; Pct; Pctr1

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