p23 Antibody (YA3131),MedChemexpress,HY-P83386

p23 Antibody (YA3131) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p23.

Host

Rabbit

Reactivity

Human,Mouse,Rat

Application

WB,ICC/IF,IP

Conjugate

Non-conjugated

Platform ID

BAB894621625

Suppliers

(1)

Biomedical Life sciences

91-9676853503

[email protected]
Country:India
City:Madīnat Ḩamad
Plot No.A-2811121/A&B/3.IP NACHARAM. ALA NACHARAM, Road N0-15, Hyderabad Medchal Malkajgiri, Telangana-500076
Master of Bioactive Molecules

MedChemexpress

Master of Bioactive Molecules

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Contact

Tel: 609-228-6898
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Email:

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Product Specifications
Verification Image
Scientific Background
Synonyms

Specifications

Namep23 Antibody (YA3131)
Cat. No.HY-P83386
Accession NumberQ15185
Gene ID (Entrez)10728
HostRabbit
RRIDAB_3105499
IsotypeIgG
SensitivityEndogenous
ReactivityHuman,Mouse,Rat
ConjugationNon-conjugated
ApplicationWB,ICC/IF,IP
Working DilutionsWB: 1:500-1:1000; ICC/IF: 1:50-1:200; IP: 1:20
ClonalityRecombinant,Monoclonal
Clone NumberYA3131
Molecular WeightPredicted band size: 19 kDa; Observed band size: 23 kDa
ImmunogenA synthetic peptide of human p23/PTGES3
PurityAffinity Purified
Appearance/FormLiquid
ShippingShipping with blue ice.
FormulationSupplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
StorageStored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Regulatory StatusResearch Use Only

Verification Image

Scientific Background

p23 is a cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). It also functions as a molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation by promoting disassembly of transcriptional regulatory complexes. Additionally, p23 facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to the recruitment of EGLN1/PHD2 to the HSP90 pathway. by similar: the function of promoting HIF alpha proteins hydroxylation.

Synonyms

PTGES3; P23; TEBP; Prostaglandin E synthase 3; Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23

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