phospho-AKT (Ser473) Polyclonal Antibody,Bioss,bs-0876r

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

WB, IHC-P, IHC-F, IF

Conjugate

Unconjugated

Platform ID

BAB665013727

Bioss

Headquarters

300 Tradecenter Dr, ste 4610Woburn, Massachusetts 01801 - U.S.A.

Bioss

Contact

Tel: +1.781.569.5821
Fax: +1.781.731.9286

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Namephospho-AKT (Ser473) Polyclonal Antibody
Cat. No.bs-0876r
Accession NumberP47196
Gene ID (Entrez)24185
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB, IHC-P, IHC-F, IF
Working DilutionsWB:1:500-2000 | IHC-P:1:100-500 | IHC-F:1:100-500 | IF:1:100-500
ClonalityPolyclonal
Concentration1ug/ul
PurityPurified by Protein A.
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
StorageShipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Scientific Background

AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.

Synonyms

Akt; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; RAC-PK-alpha; Akt1

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