phospho-Smad2 (Ser255) Recombinant Antibody,Bioss,bsm-52204r

Host

Rabbit

Reactivity

Human, Mouse

Application

WB, IHC-P, IHC-F, IF, ICC/IF

Conjugate

Unconjugated

Platform ID

BAB851646629

Bioss

Headquarters

300 Tradecenter Dr, ste 4610Woburn, Massachusetts 01801 - U.S.A.

Bioss

Contact

Tel: +1.781.569.5821
Fax: +1.781.731.9286

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Namephospho-Smad2 (Ser255) Recombinant Antibody
Cat. No.bsm-52204r
Accession NumberQ15796
Gene ID (Entrez)4087
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse
ConjugationUnconjugated
ApplicationWB, IHC-P, IHC-F, IF, ICC/IF
Working DilutionsWB:1:1000IHC1:50-200 | IHC-P:1:200-400 | IHC-F:1:100-500 | IF: | ICC/IF:1:50-100
ClonalityRecombinant
Concentration1ug/ul
PurityPurified by Protein A.
Formulation0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
StorageStore at -20°C for 12 months.

Scientific Background

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Synonyms

JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; Mad-related protein 2; SMAD family member 2; SMAD 2; Smad2

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