Search results for Cellular Tumor Antigen p53 Phospho-Thr18 (TP53 pT18) Antibody
Cellular Tumor Antigen p53 Phospho-Thr18 (TP53 pT18) Antibody, Abbexa, abx000511
TP53 (pT18) Antibody is a Rabbit Polyclonal antibody against TP53 (pT18). This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Cellular Tumor Antigen p53 Phospho-Thr18 (TP53 pT18) Antibody, Abbexa, abx119197
p53 (pT18) Antibody is a Rabbit Polyclonal antibody against p53 (pT18).
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
Conjugation
Unconjugated
Cellular Tumor Antigen p53 Phospho-Thr18 (TP53 pT18) Antibody, Abbexa, abx031899
Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC, DB
Conjugation
Unconjugated
Cellular Tumor Antigen p53 Phospho-Thr18 (TP53 pT18) Antibody, Abbexa, abx332933
TP53 (pT18) Antibody is a Rabbit Polyclonal against TP53 (pT18).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Cellular Tumor Antigen p53 Phospho-Thr18 (TP53 pT18) Antibody, Abbexa, abx327410
TP53 (pT18) Antibody is a Rabbit Polyclonal against TP53 (pT18).
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
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