Search results for Cyclin Dependent Kinase 5 Activator 1 (CDK5R1) Antibody
Cyclin Dependent Kinase 5 Activator 1 (CDK5R1) Antibody, Abbexa, abx329458
CDK5R1 Antibody is a Rabbit Polyclonal against CDK5R1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Cyclin Dependent Kinase 5 Activator 1 (CDK5R1) Antibody, Abbexa, abx033654
p35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5) ; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Cyclin Dependent Kinase 5 Activator 1 (CDK5R1) Antibody, Abbexa, abx013614
Rabbit polyclonal antibody against CDK5R1 protein. Immunogen region is N-terminal.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IF/ICC
Conjugation
Unconjugated
Cyclin Dependent Kinase 5 Activator 1 (CDK5R1) Antibody, Abbexa, abx037827
Rabbit Polyclonal against the CDK5R1 protein.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC
Conjugation
Unconjugated
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