Search results for DNA Methyltransferase 1 (DNMT1) Antibody
DNA Methyltransferase 1 (Dnmt1) Antibody, Abbexa, abx148089
DNA Methyltransferase 1 (Dnmt1) Antibody is a Rabbit Polyclonal antibody for the detection of DNMT1. Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306).
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
DNA Methyltransferase 1 (DNMT1) Antibody, Abbexa, abx224399
DNMT1 Antibody is a Mouse Monoclonal against DNMT1.
Host
Mouse
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
DNA Methyltransferase 1 (DNMT1) Antibody, Abbexa, abx224400
DNMT1 Antibody is a Mouse Monoclonal against DNMT1.
Host
Mouse
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
DNA Methyltransferase 1 (DNMT1) Antibody, Abbexa, abx025678
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. Dnmt1 also cooperates with Rb to repress transcription from promoters containing E2Fbinding sites suggesting a link between DNA methylation, histone deacetylase and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
DNA Methyltransferase 1 (DNMT1) Antibody, Abbexa, abx211440
DNMT1 Antibody is a Rabbit Polyclonal against DNMT1.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
DNA Methyltransferase 1 (DNMT1) Antibody, Abbexa, abx444924
DNMT1 Antibody is a Mouse Monoclonal antibody against DNMT1.
Host
Mouse
Reactivity
Human, Mouse, Fish, Zebrafish
Applications
WB, IHC, IP, ChIP
Conjugation
Unconjugated
DNA Methyltransferase 1 (DNMT1) Antibody, Abbexa, abx102430
Polyclonal Antibody to DNA Methyltransferase 1 (DNMT1).
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
DNA Methyltransferase 1 (DNMT1) Antibody, Abbexa, abx038164
Rabbit Polyclonal against the DNMT1 protein.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
DNA Methyltransferase 1 (DNMT1) Antibody, Abbexa, abx312682
DNMT1 Antibody is a Rabbit Polyclonal against DNMT1.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC, IF/ICC
Conjugation
Unconjugated
DNA Methyltransferase 1 (DNMT1) Antibody, Abbexa, abx431213
DNMT1 Antibody is a Goat Polyclonal antibody against DNMT1.
Host
Goat
Reactivity
Human
Applications
P-ELISA, WB, IHC
Conjugation
Unconjugated
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