Search results for DNA Mismatch Repair Protein Msh2 (MSH2) Antibody
DNA Mismatch Repair Protein Msh2 (MSH2) Antibody, Abbexa, abx235371
MSH2 Antibody is a Rabbit Polyclonal against MSH2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC, FCM, IP
Conjugation
Unconjugated
DNA Mismatch Repair Protein Msh2 (MSH2) Antibody, Abbexa, abx235372
MSH2 Antibody is a Mouse Monoclonal against MSH2.
Host
Mouse
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
DNA Mismatch Repair Protein Msh2 (MSH2) Antibody, Abbexa, abx034997
Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
Host
Mouse
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
DNA Mismatch Repair Protein Msh2 (MSH2) Antibody, Abbexa, abx113898
DNA Mismatch Repair Protein Msh2 Antibody is a Rabbit Polyclonal antibody against DNA Mismatch Repair Protein Msh2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
DNA Mismatch Repair Protein Msh2 (MSH2) Antibody, Abbexa, abx014049
Rabbit polyclonal antibody against MSH2 protein. Immunogen region is Internal.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC, IF/ICC
Conjugation
Unconjugated
DNA Mismatch Repair Protein Msh2 (MSH2) Antibody, Abbexa, abx338759
MSH2 Antibody is a Rabbit Polyclonal against MSH2.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC, IP
Conjugation
Unconjugated
DNA Mismatch Repair Protein Msh2 (MSH2) Antibody, Abbexa, abx455358
DNA Mismatch Repair Protein Msh2 (MSH2) Antibody is a Rabbit polyclonal antibody for the detection of Human DNA Mismatch Repair Protein Msh2 (MSH2).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
DNA Mismatch Repair Protein Msh2 (MSH2) Antibody, Abbexa, abx326761
MSH2 Antibody is a Rabbit Polyclonal against MSH2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC, IF/ICC
Conjugation
Unconjugated
DNA Mismatch Repair Protein Msh2 (MSH2) Antibody, Abbexa, abx026331
MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. [provided by RefSeq].
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IF/ICC, FCM
Conjugation
Unconjugated
DNA Mismatch Repair Protein Msh2 (MSH2) Antibody, Abbexa, abx001036
MSH2 Antibody is a Rabbit Polyclonal antibody against MSH2. This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
Conjugation
Unconjugated
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