Search results for E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody
E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody, Abbexa, abx111410
E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody is a Rabbit Polyclonal antibody against E3 Ubiquitin-Protein Ligase CBL-B (CBLB).
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody, Abbexa, abx231318
CBLB Antibody is a Rabbit Polyclonal against CBLB.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody, Abbexa, abx001636
CBLB Antibody is a Rabbit Polyclonal antibody against CBLB. CBLB (E3 ubiquitin protein ligase CBL-B) is a protein-coding gene. Diseases associated with CBLB include cannabis dependence. GO annotations related to this gene include signal transducer activity and calcium ion binding. An important paralog of this gene is CBLC.
Host
Rabbit
Reactivity
Human, Mouse
Applications
WB
Conjugation
Unconjugated
E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody, Abbexa, abx034055
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. It also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. It may also be involved in EGFR ubiquitination and internalization.
Host
Rabbit
Reactivity
Rat
Applications
ELISA, WB, IHC, FCM
Conjugation
Unconjugated
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