Search results for ETS Translocation Variant 5 (ETV5) Antibody
ETS Translocation Variant 5 (ETV5) Antibody, Abbexa, abx025877
The ETS family of transcription factors, characterized by an evolutionarily conserved DNA-binding domain, regulates expression of more than 300 target genes by binding to a purine-rich GGAA/T core sequence. Depending on the cellular context, they can function as transactivators or transrepressors. Ets proteins have been implicated in regulation of gene expression during a variety of biological processes, including growth control, transformation, T-cell activation, and developmental programs in many organisms. Signals regulating cell growth are transmitted from outside the cell to the nucleus by growth factors and their receptors, G-proteins, kinases and transcription factors. It was shown that ETS signal transduction is implicated in hematopoiesis and angiogenesis at the earliest stages of embryogenesis, and is later involved in tissue development. Deregulated expression and/or formation of chimeric fusion proteins of the ETS family due to proviral insertion or chromosome translocation is associated with leukemias and with specific types of solid tumors.1 Among the multiple Ets proteins, the PEA3 group consists of ETV1 (Ets variant gene 1; also called ER81), ETV4 (also called PEA3) and ETV5 (also called ERM). All three members are 95% identical in the ETS domain and more than 85% in the acidic transactivation domain. Several studies suggest that the PEA3 group proteins are involved in intestinal tumors, gastric cancer, and breast cancer metastasis. In nearly all Ewing?s sarcoma tumors, EWS, which encodes a RNA-binding protein, is fused by chromosomal translocation to an Ets gene, including FLI, ERG, ETV4, and ETV1. This results in the expression of chimeric proteins that may be important in tumor cell transformation.2 Recently, it was reported that TMPRSS2, an AR-regulated gene, is fused by translocation to the ETV1, ERG, or ETV4 gene in a subset of prostate cancers. These findings suggest an important role for PEA3 proteins in prostate cancer.3 In addition Ets family members have been correlated to tumor progression by upregulating the expression of matrix-degrading proteases. The acquisition of a migratory phenotype by the epithelial tumor cells together with the remodeling of the extracellular matrix must accompany the process of cancer cell invasion. Indeed, ETV5 has been shown to act through matrix metalloproteinase-2 gelatinolytic activity to confer invasive capabilities, associated with an initial switch to myometrial infiltration.4.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, FCM
Conjugation
Unconjugated
ETS Translocation Variant 5 (ETV5) Antibody, Abbexa, abx405701
This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. Human ETS Translocation Variant 5 (ETV5) Antibody is a Rabbit polyclonal against ETS Translocation Variant 5 (ETV5).
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
ETS Translocation Variant 5 (ETV5) Antibody, Abbexa, abx010753
ETS variant 5,transcription factor of the ETS family,divergent member of the winged helix-turn-helix superfamily,expressed in brain,placenta and other tissues involved in development. Tissue specificity: Ubiquitous. ERM is expressed in Sertoli cells and spermatogonial stem cells (SSCs). Studies on knockout mice have shown that it is required for SSC self-renewal but not differentiation, thus affected mice exhibit progressive germ cell depletion.
Host
Mouse
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
ETS Translocation Variant 5 (ETV5) Antibody, Abbexa, abx341785
ETS Translocation Variant 5 (ETV5) Antibody is a Rabbit Polyclonal antibody for the detection of Human ETV5.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
ETS Translocation Variant 5 (ETV5) Antibody (Biotin), Abbexa, abx341788
ETS Translocation Variant 5 (ETV5) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin for the detection of Human ETV5.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
Biotin
ETS Translocation Variant 5 (ETV5) Antibody (FITC), Abbexa, abx341787
ETS Translocation Variant 5 (ETV5) Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC for the detection of Human ETV5.
Host
Rabbit
Reactivity
Human
Applications
Conjugation
FITC
ETS Translocation Variant 5 (ETV5) Antibody (HRP), Abbexa, abx341786
ETS Translocation Variant 5 (ETV5) Antibody (HRP) is a Rabbit Polyclonal antibody conjugated to HRP for the detection of Human ETV5.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
HRP
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