Search results for FLASH antibody

FLASH antibody, Genetex, GTX28420

FLASH antibody, Genetex, GTX70367

FLASH antibody, Covalab, Ref 00101298

FLASH antibody, Covalab, Ref 00101299

Anti-FLASH antibody, Abcam, AB8420

A novel mammalian CED-4 homologous was recently identified and cloned in mouse (1) and human (2) and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8 (1). There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity (1,2).