Search results for GFI1B

GFI1b (D3G2) Rabbit Monoclonal Antibody#5849, Cell Signaling Technology (CST), 5849

GFI1b (D3G2) Rabbit Monoclonal Antibody recognizes endogenous levels of total GFI1b protein.

GFI1b antibody, Genetex, GTX50844

Anti-GFI1B antibody, Abcam, AB167304

Anti-GFI1B Polyclonal Antibody (HB304014), abinScience, HB304014

Zinc Finger Protein Gfi-1b (GFI1B) Antibody, Abbexa, abx034803

Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.

Mouse Zinc finger protein Gfi-1b (GFI1B) ELISA Kit, Abbexa, abx525160

Mouse Zinc finger protein Gfi-1b (GFI1B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Zinc finger protein Gfi-1b concentrations in tissue homogenates, cell lysates and other biological fluids.

Human Zinc Finger Protein Gfi-1b (GFI1B) ELISA Kit, Abbexa, abx525159

Human Zinc Finger Protein Gfi-1b (GFI1B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Zinc Finger Protein Gfi-1b (GFI1B) concentrations in tissue homogenates, cell lysates and other biological fluids.