Search results for GSK3 alpha Antibody

GSK3 alpha Antibody, Abbexa, abx015751

Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily.It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun.GSK3 phosphorylates glycogen synthase and thereby inactivates it.Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis.GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta.The two isoforms share 97% sequence similarity within their catalytic domains.GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

GSK3 alpha Antibody, Abbexa, abx010857

Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily, GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

GSK3 alpha antibody, Genetex, GTX50368

GSK3 alpha Antibody, Abbexa, abx012858

Rabbit polyclonal antibody against GSK3 alpha protein. Immunogen region is N-terminal.

GSK3 alpha Antibody, Abbexa, abx033883

Glycogen synthase kinase 3-alpha (GSK3A) is a multifunctional protein serine kinase implicated in the control of several regulatory proteins including glycogen synthase and transcription factors. It also plays a role in the WNT and PI3K signaling pathways.1 Under resting conditions GSK3A and its homologs are highly phosphorylated at tyr279 in the phosphorylation loop.2 Constitutive phosphorylation of this tyrosine is important for kinase activity. Dephosphorylation of tyr279 after mitogen activation is accompanied by kinase inactivation. PKA as well as PI3K-activated PKB inactivate GSK3A by phosphorylation at ser21.3 Lysophosphatidic acid primarily utilizes a PKC-dependent pathway to modulate GSK3 and certain growth factors (e.g., PDGFB), which control GSK3 mainly through PIK3-PKB, are able to regulate GSK3 through an alternative, redundant phospholipase-C-gamma-PKC pathway.4 Alzheimer disease (AD) is associated with increased production and aggregation of amyloid-beta-40 and 42 peptides into plaques. GSK3A is required for maximal production of the beta-amyloid-40 and 42 peptides generated from the amyloid precursor protein (APP) by presenilin (PSEN1) dependent gamma-secretase cleavage.5 In vitro, lithium, a GSK3A inhibitor, blocked the production of the beta-amyloid peptides by interfering with the gamma-secretase step. In mice expressing familial AD-associated mutations in APP and PSEN1, lithium reduced the levels of beta-amyloid peptides GSK3A also phosphorylates the tau protein (MAPT), the principal component of neurofibrillary tangles in AD, and suggested that inhibition of GSK3A may offer a new therapeutic approach to AD.

GSK3 alpha Antibody, Abbexa, abx015750

Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily,GSK3 subsubfamily.It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun.GSK3 phosphorylates glycogen synthase and thereby inactivates it.Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis.GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta.The two isoforms share 97% sequence similarity within their catalytic domains.GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

GSK3 alpha antibody, Genetex, GTX66620

GSK3 alpha Antibody (YA4055), MedChemexpress, HY-P84358

GSK3 alpha Antibody (YA4055) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GSK3 alpha.

GSK3 alpha Antibody (YA4886), MedChemexpress, HY-P85194

GSK3 alpha Antibody (YA4886) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to GSK3 alpha.

GSK3 alpha Antibody (YA6176), MedChemexpress, HY-P86484

GSK3 alpha Antibody (YA6176) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GSK3 alpha.