Search results for Gevokizumab ELISA Kit
Gevokizumab ELISA Kit, ProteoGenix, KPTX132
Description of Gevokizumab ELISA Kit Gevokizumab ELISA Kit: A Powerful Tool for Detecting and Studying Therapeutic Antibody Gevokizumab ELISA Kit: A Scientific Overview The Gevokizumab ELISA Kit is a highly sensitive and specific tool used for the detection and quantification of the therapeutic antibody, Gevokizumab, in various biological samples. This kit is designed to provide researchers with a reliable and efficient method for studying the structure, activity, and application of this important therapeutic target. Structure of Gevokizumab Gevokizumab is a humanized monoclonal antibody that targets interleukin-1 beta (IL-1β), a pro-inflammatory cytokine involved in various inflammatory diseases such as rheumatoid arthritis, psoriasis, and type 2 diabetes. The antibody is composed of two heavy chains and two light chains, and has a molecular weight of approximately 150 kDa. Principle of Gevokizumab ELISA Kit The Gevokizumab ELISA Kit is based on the principle of enzyme-linked immunosorbent assay (ELISA), a widely used technique for the detection and quantification of specific proteins in biological samples. This kit utilizes a sandwich ELISA format, where the antibody-coated plate captures the target antigen (Gevokizumab) present in the sample. The captured antibody is then detected by a secondary enzyme-labeled antibody, and the signal is amplified by the addition of a substrate, resulting in a measurable color change. Activity of Gevokizumab Gevokizumab is a potent inhibitor of IL-1β, which plays a crucial role in the inflammatory response. By binding to IL-1β, Gevokizumab prevents its interaction with its receptor and subsequent downstream signaling, thus reducing inflammation and associated symptoms. This activity has been demonstrated in various preclinical and clinical studies, making Gevokizumab a promising therapeutic target for inflammatory diseases. Application of Gevokizumab ELISA Kit The Gevokizumab ELISA Kit has a wide range of applications in the field of drug development and research. It can be used to measure the concentration of Gevokizumab in various biological samples, such as serum, plasma, and cell culture supernatant, providing valuable information on drug pharmacokinetics and pharmacodynamics. This kit can also be used to screen and select high-affinity Gevokizumab clones during antibody development, as well as to monitor the stability and quality of Gevokizumab during manufacturing and storage. Conclusion The Gevokizumab ELISA Kit is a powerful tool for detecting and studying the therapeutic antibody, Gevokizumab. Its high sensitivity and specificity, along with its easy-to-use format, make it an essential kit for researchers working on Gevokizumab and IL-1β-related diseases. With the increasing interest in Gevokizumab as a potential treatment for various inflammatory conditions, this kit will continue to play a crucial role in advancing drug development and research in this field.
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Gevokizumab ELISA Kit, Abbexa, abx395021
Gevokizumab ELISA Kit is a quantitative ELISA kit for detection of Gevokizumab.Gevokizumab (XOMA-052) was developed by XOMA Ltd., USA and represents a humanized IgG2 kappa antibody. XOMA-052 binds to IL-1β with high affinity leading to reduced binding affinity of the cytokine to its signaling receptor. Since gevokizumab does not influence the affinity of IL-1β for its decoy and soluble inhibitory receptors the endogenous regulatory mechanisms involving the clearance and inhibitory receptors also contribute to the effect of the antibody [6]. In August 2012 the FDA granted orphan drug status to gevokizumab for the treatment of noninfectious intermediate uveitis, posterior uveitis, panuveitis, and chronic noninfectious anterior uveitis. A single intravenous injection of the substance was also shown to lead to complete resolution of intraocular inflammation in Behçet’s uveitis.
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Human
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