Search results for Golimumab

Golimumab Biosimilar – Anti-TNFA, TNF alpha mAb – Research Grade, ProteoGenix, PX-TA1129

Description of Golimumab Biosimilar - Anti-TNFA, TNF alpha mAb - Research Grade General information on Anti-TNFA/TNF alpha(Homo sapiens) (Golimumab) Monoclonal Antibody Golimumab is a human IgG1 alpha monoclonal antibody, developped from genetically engineered mice immunized with human TNFalpha. Golimumab binds to and inhibits soluble and transmembrane human TNFalpha. Elevated TNFalpha is related to chronic inflammation. Therefore, golimumab can be used in adults,for the treatment of active rheumatoid arthritis (RA), active psoriatic arthritis ( PsA), active ankylosing spondylitis (AS), ulcerative colitis (UC). In the United States and Canada, golimumab is sold under the Simponi® brand. The FDA label includes a black box that warns of serious infections and malignant tumors.

Golimumab, Abbexa, abx831088

Golimumab is a monoclonal antibody biosimilar expressed in CHO cells, targeting TNFA/TNF alpha, for use in laboratory research applications. This product is not suitable for use as medicines or in human, therapeutic or diagnostic applications. Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients with moderate to severe active rheumatoid arthritis (RA), (ii) alone or as an adjunct to methotrexate treatment in patients with active psoriatic arthritis (PsA), (iii) as a single agent in patients with active ankylosing spondylitis (AS), and (iv) as a single agent in patients with moderate to severe ulcerative colitis (UC) who require chronic steroids or have experienced intolerance or only a partial response to previous medications. In the U. S. and Canada, golimumab is marketed under the brand name Simponi®. The FDA label includes a black box warning of serious infections and malignancy. Additionally in children and adolescents taking golimumab, there have been lymphoma and other malignancies observed. As a human monoclonal antibody, golimumab binds and inhibits soluble and transmembrane human TNFα. Inhibition of TNFα prevents it binding to its receptors, which prevents both leukocyte infiltration through prevention of cell adhesion proteins such as E-selectin, ICAM-1 and VCAM-1, and pro-inflammatory cytokine secretion such as IL-6, IL-8, G-CSF and GM-CSF in vitro. Consequently, in patients with chronic inflammatory conditions, decreases in ICAM-1 and IL-6 as well as C-reactive protein (CRP), matrix metalloproteinase 3 (MMP-3), and vascular endothelial growth factor (VEGF) were observed.

Golimumab Antibody, Abbexa, abx376587

Golimumab Antibody is a rabbit polyclonal antibody for the detection of Golimumab.

Golimumab ELISA Kit, ProteoGenix, KPTX129

Description of Golimumab ELISA Kit Golimumab ELISA Kit: A Powerful Tool for Detecting and Quantifying Golimumab in Biological Samples Golimumab is a monoclonal antibody that has been developed as a therapeutic agent for treating autoimmune disorders such as rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. It works by binding to a specific protein called tumor necrosis factor alpha (TNF-α), which plays a key role in the inflammatory response. By blocking the action of TNF-α, golimumab helps reduce inflammation and alleviate symptoms of these diseases. As with any therapeutic agent, it is important to accurately measure the levels of golimumab in a patient’s body to ensure proper dosing and treatment efficacy. This is where the Golimumab ELISA Kit comes into play. ELISA (enzyme-linked immunosorbent assay) is a widely used technique for detecting and quantifying specific proteins in biological samples. The Golimumab ELISA Kit is a powerful tool that utilizes this technique to detect and quantify golimumab in various biological samples, such as serum, plasma, and cell culture supernatants. Structure of the Golimumab ELISA Kit The Golimumab ELISA Kit consists of several components, including microtiter plates coated with a specific antibody against golimumab, golimumab standards, and detection reagents. The microtiter plates are pre-coated with the capture antibody, which specifically binds to golimumab. The standards are used to generate a standard curve for quantification of golimumab in the samples. The detection reagents include an enzyme-labeled golimumab and a substrate that produces a colorimetric signal when acted upon by the enzyme. The principle of the Golimumab ELISA Kit is based on the specific binding of golimumab to the capture antibody on the microtiter plate. Any golimumab present in the sample will bind to the capture antibody, while any unbound proteins are washed away. The enzyme-labeled golimumab is then added, which binds to the captured golimumab. The substrate is then added, and the color change is measured using a spectrophotometer. The intensity of the color is directly proportional to the amount of golimumab present in the sample, allowing for accurate quantification. Activity of the Golimumab ELISA Kit The Golimumab ELISA Kit has a high sensitivity and specificity for golimumab, meaning it can accurately detect and quantify very low levels of golimumab in biological samples. It has a wide dynamic range, allowing for the measurement of golimumab at various concentrations. The kit also has a high reproducibility, with low intra- and inter-assay variability. This ensures that results obtained from different experiments or different operators are consistent and reliable. The Golimumab ELISA Kit is also a rapid and convenient method for golimumab detection, with a total assay time of less than 4 hours. This makes it a valuable tool for high-throughput screening of samples in research and clinical settings. Application of the Golimumab ELISA Kit The Golimumab ELISA Kit has a wide range of applications in both research and clinical settings. It can be used to measure golimumab levels in patient samples to monitor treatment efficacy and guide dosing decisions. It is also a valuable tool for studying the pharmacokinetics of golimumab, as it allows for the measurement of drug levels in various biological matrices over time. In addition, the Golimumab ELISA Kit can be used in pre-clinical studies to assess the pharmacokinetics and immunogenicity of golimumab in animal models. It can also be used to measure golimumab levels in cell culture supernatants, which is useful for optimizing cell-based assays and studying the mechanism of action of golimumab. In Conclusion The Golimumab ELISA Kit is a

Golimumab ELISA Kit, Abbexa, abx395018

Golimumab ELISA Kit is a quantitative ELISA kit for detection of Golimumab.Golimumab (Simponi®) is a human immunoglobulin G1 monoclonal antibody which is specific for pro-inflammatory cytokine, tumor necrosis factor-a (TNFa). In 2009, it was approved by FDA for the treatment of rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis in adult patients. Elevated levels of TNF are found in the synovial fluid of rheumatoid arthritis, including juvenile idiopathic arthritis, psoriatic arthritis, and ankylosing spondylitis patients and play an important role in both the pathologic inflammation and the joint destruction that are hallmarks of these diseases. Increased levels of TNF are also found in psoriasis (Ps) plaques. Golimumab binds to both the soluble and transmembrane bioactive forms of human TNF and prevent TNF from binding to its receptors and finally inhibits biological activity of TNF.

Anti-Golimumab Polyclonal Antibody, AntibodySystem, PAB94403

Golimumab Biosimilar - Research Grade, ichor.bio, ICH5312

Detects human TNFA

Human Anti-Golimumab ELISA Kit, Abbexa, abx392368

Human Anti-Golimumab ELISA Kit is a quantitative ELISA kit for detection of antibodies against Golimumab.