Search results for IKZF1

Anti-IKZF1 Antibody (R2E31), AntibodySystem, RHG52101

Anti-IKZF1 Antibody (R3S45), AntibodySystem, RHG52102

Anti-IKZF1 Antibody (R3S46), AntibodySystem, RHG52103

Mouse Monoclonal Antibody to IKZF1, ProMab, 32119

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

Mouse Monoclonal Antibody to IKZF1, ProMab, 32120

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

DNA-Binding Protein Ikaros (IKZF1) Antibody, Abbexa, abx025640

DNA-binding protein Ikaros (IKZF1) Antibody is a Rabbit Polyclonal antibody against DNA-binding protein Ikaros (IKZF1).

DNA-Binding Protein Ikaros (IKZF1) Antibody, Abbexa, abx113101

DNA-binding protein Ikaros (IKZF1) Antibody is a Rabbit Polyclonal antibody against DNA-binding protein Ikaros (IKZF1).

DNA-Binding Protein Ikaros (IKZF1) Antibody, Abbexa, abx430401

DNA-binding protein Ikaros (IKZF1) Antibody is a Goat Polyclonal antibody against DNA-binding protein Ikaros (IKZF1).

DNA-Binding Protein Ikaros (IKZF1) Antibody, Abbexa, abx307001

DNA-binding protein Ikaros (IKZF1) Antibody is a Rabbit Polyclonal against DNA-binding protein Ikaros (IKZF1).

DNA-Binding Protein Ikaros (IKZF1) Antibody, Abbexa, abx234204

DNA-binding protein Ikaros (IKZF1) Antibody is a Rabbit Polyclonal against DNA-binding protein Ikaros (IKZF1).