Search results for INK4A antibody

hp16-INK4A Antibody, Abbexa, abx030816

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

CDKN2A/p16INK4a Antibody (YA508)(PBS only), MedChemexpress, HY-P80615A

CDKN2A/p16INK4a Antibody (YA508)(PBS only) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDKN2A/p16INK4a.

CDKN2A/p16INK4a Antibody (YA508), MedChemexpress, HY-P80615

CDKN2A/p16INK4a Antibody (YA508) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDKN2A/p16INK4a.

CDKN2A/p16INK4a Antibody (YA3494), MedChemexpress, HY-P80992

CDKN2A/p16INK4a Antibody (YA3494) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDKN2A/p16INK4a.

CDKN2A / p14ARF antibody, Genetex, GTX129902

CDKN2A / p14ARF antibody, Genetex, GTX129903

p14ARF (isoform 3) antibody, Internal, Genetex, GTX88429

Cyclin-Dependent Kinase Inhibitor 2A / P16-INK4A Antibody, Abbexa, abx236064

CDKN2A / P16-INK4A Antibody is a Rabbit Polyclonal against CDKN2A. CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively-spliced variants encoding distinct proteins have been reported, and two are related, named p16-INK4 and p14 respetively, sharing 50% identity. The third one is completely stuctually un-related, called p14(ARF) or p19(ARF). This antibody reacts with p16 specifically. P16 plays an important role in regulating the cell cycle, and mutations in p16 increase the risk of developing a variety of cancers, notably melanoma.