Search results for Insulin Receptor (INSR) Antibody
Insulin Receptor (INSR) Antibody, Abbexa, abx033580
INSR is a receptor that binds insulin and has a tyrosine-protein kinase activity. Autophosphorylation activates the kinase activity. This Type I mebrane protein is composed of a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. After being transported from the endoplasmic reticulum to the Golgi apparatus, the single glycosylated precursor is further glycosylated and then cleaved, followed by its transport to the plasma membrane. Defects in INSR are the cause of insulin resistance of various forms, including mild insulin-resistant diabetes mellitus with acanthosis nigricans, minor physical abnormalities and sometimes polycystic ovaries. Insulin resistance associated with acanthosis nigricans, hirsutism and hyperandrogenism is referred to as insulin resistance type A. Defects in INSR are the cause of Rabson-Mendenhall syndrome, also known as Mendenhall syndrome. It is a severe insulin resistance syndrome characterized by insulin-resistant diabetes mellitus with pineal hyperplasia and somatic abnormalities. Typical features include coarse, senile-appearing facies, dental and skin abnormalities, abdominal distension, and phallic enlargement. Inheritance is autosomal recessive. Defects in INSR are the cause of leprechaunism, also known as Donohue syndrome. Leprechaunism represents the most severe form of insulin resistance syndrome, characterized by intrauterine and postnatal growth retardation and death in early infancy. Inheritance is autosomal recessive. Defects in INSR may be associated with noninsulin-dependent diabetes mellitus.
Host
Rabbit
Reactivity
Mouse
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Insulin Receptor (INSR) Antibody, Abbexa, abx113158
Insulin Receptor (INSR) Antibody is a Rabbit Polyclonal antibody against Insulin Receptor (INSR).
Host
Rabbit
Reactivity
Human, Rat
Applications
ELISA, WB, IP
Conjugation
Unconjugated
Insulin Receptor (INSR) Antibody, Abbexa, abx323163
INSR Antibody is a Rabbit Polyclonal against INSR.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC, IF/ICC
Conjugation
Unconjugated
Insulin Receptor (INSR) Antibody, Abbexa, abx000670
INSR Antibody is a Rabbit Polyclonal antibody against INSR. After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IP
Conjugation
Unconjugated
Insulin Receptor (INSR) Antibody, Abbexa, abx326379
INSR Antibody is a Rabbit Polyclonal against INSR.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IF/ICC
Conjugation
Unconjugated
Insulin Receptor (INSR) Antibody, Abbexa, abx101322
Polyclonal Antibody to Insulin Receptor (INSR).
Host
Rabbit
Reactivity
Mouse
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Insulin Receptor (INSR) Antibody, Abbexa, abx101319
Polyclonal Antibody to Insulin Receptor (INSR).
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Insulin Receptor (INSR) Antibody, Abbexa, abx402023
Insulin Receptor (INSR) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human INSR.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IF/ICC
Conjugation
Unconjugated
Insulin Receptor (INSR) Antibody, Abbexa, abx403178
Human Insulin Receptor (INSR) Antibody is a Mouse monoclonal against Insulin Receptor (INSR).
Host
Mouse
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Insulin Receptor (INSR) Antibody, Abbexa, abx302359
INSR Antibody is a Rabbit Polyclonal against INSR.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC, IF/ICC
Conjugation
Unconjugated
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