Search results for LAMP-2

LAMP-2, Human, clone C10, Hycult Biotech, HM2373

Monoclonal antibody C10 recognizes human lysosome-associated membrane protein-2 (LAMP-2; CD107b). LAMP-2 a heavily glycosylated membrane protein expressed in lysosomes. It is a member of a family of membrane glycoproteins like MAP-1, LIMP2 and DC-LAMP. It is a heavily glycosylated protein of 383 amino acids. LAMP-2 is expressed in a broad panel of tissues like placenta, lung, liver and kidney. Glycosylation is dependent on cell type and activation status. LAMP-2 exists in three splice variants LAMP-2A, LAMP-2B and LAMP-2C. They differ in their sequence in the transmembrane and cytoplasmic domain that effects their function. LAMP-2 is important for control of lysosomal activity and traffic across the lysosomal membranes. Its ability to mediate fusion between autophagosomes and lysosomes makes it important for the process of autophagy. The protein is also involved in cholesterol transport and cytoplasmic antigen MHCII presentation. Normally LAMP-2 is expressed at low levels on the cell surface. The degree of surface expression is dependent on the cell type and state of activation. Genetic deficiency of LAMP-2 causes Danon disease inducing cardiomyopathy and myopathy. Recent studies show also involvement in ANCA-vasculitis.

LAMP-2, Human, clone C5, Hycult Biotech, HM2371

Monoclonal antibody HM2371, clone C5 recognizes human lysosome-associated membrane protein-2 (LAMP-2; CD107b). LAMP-2 is a heavily glycosylated membrane protein expressed in lysosomes of 383 amino acids. It is a member of a family of membrane glycoproteins like MAP-1, LIMP2 and DC-LAMP. LAMP-2 is expressed in a broad panel of tissues like placenta, lung, liver and kidney. Glycosylation is dependent on cell type and activation status. LAMP-2 exists in three splice variants LAMP-2A, LAMP-2B and LAMP-2C. They differ in their sequence in the transmembrane and cytoplasmic domain that effects their function. LAMP-2 is important for control of lysosomal activity and traffic across the lysosomal membranes. Its ability to mediate fusion between auto phagosomes and lysosomes makes it important for the process of autophagy. The protein is also involved in cholesterol transport and cytoplasmic antigen MHCII presentation. Normally LAMP-2 is expressed at low levels on the cell surface. The degree of surface expression is dependent on the cell type and state of activation. Genetic deficiency of LAMP-2 causes Danon disease inducing cardiomyopathy and myopathy. Recent studies show also involvement in ANCA-vasculitis.

LAMP-2, Human, clone C8, Hycult Biotech, HM2372

Monoclonal antibody HM2372, clone C8 recognizes human lysosome-associated membrane protein-2 (LAMP-2; CD107b). LAMP-2 is a heavily glycosylated membrane protein expressed in lysosomes of 383 amino acids. It is a member of a family of membrane glycoproteins like MAP-1, LIMP2 and DC-LAMP. LAMP-2 is expressed in a broad panel of tissues like placenta, lung, liver and kidney. Glycosylation is dependent on cell type and activation status. LAMP-2 exists in three splice variants LAMP-2A, LAMP-2B and LAMP-2C. They differ in their sequence in the transmembrane and cytoplasmic domain that effects their function. LAMP-2 is important for control of lysosomal activity and traffic across the lysosomal membranes. Its ability to mediate fusion between auto phagosomes and lysosomes makes it important for the process of autophagy. The protein is also involved in cholesterol transport and cytoplasmic antigen MHCII presentation. Normally LAMP-2 is expressed at low levels on the cell surface. The degree of surface expression is dependent on the cell type and state of activation. Genetic deficiency of LAMP-2 causes Danon disease inducing cardiomyopathy and myopathy. Recent studies show also involvement in ANCA-vasculitis.

LAMP2 Antibody (YA3778)(PBS only), MedChemexpress, HY-P84081A

LAMP2 Antibody (YA3778) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to LAMP2.

LAMP2 antibody, Genetex, GTX30881

LAMP2 antibody, Genetex, GTX32699

LAMP2 Antibody (YA3778), MedChemexpress, HY-P84081

LAMP2 Antibody (YA3778) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to LAMP2.

LAMP2 Antibody (YA6257), MedChemexpress, HY-P86565

LAMP2 Antibody (YA6257) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LAMP2.

LAMP2 antibody [GL2A7], Genetex, GTX13524

[KO Validated] LAMP2 Rabbit PolymAb®, ABclonal, A26781PM