Search results for Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1) Antibody
Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1) Antibody, Abbexa, abx230543
ARH Antibody is a Rabbit Polyclonal against ARH.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1) Antibody, Abbexa, abx033818
LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. This adapter protein is required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. This protein may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits, and may also be involved in the internalization of other LDLR family members. Mutations in the LDLRAP1 gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1) Antibody, Abbexa, abx430017
ARH Antibody is a Goat Polyclonal antibody against ARH.
Host
Goat
Reactivity
Human
Applications
P-ELISA, IF/ICC
Conjugation
Unconjugated
Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1) Antibody, Abbexa, abx033819
LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. This adapter protein is required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. This protein may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits, and may also be involved in the internalization of other LDLR family members. Mutations in the LDLRAP1 gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
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