Search results for Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody
Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody, Abbexa, abx001836
MBD3 Antibody is a Rabbit Polyclonal antibody against MBD3. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB
Conjugation
Unconjugated
Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody, Abbexa, abx013349
Rabbit polyclonal antibody against MBD3 protein. Immunogen region is C-terminal.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB
Conjugation
Unconjugated
Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody, Abbexa, abx318139
MBD3 Antibody is a Rabbit Polyclonal against MBD3.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Methyl-Cpg-Binding Domain Protein 3 (MBD3) Antibody, Abbexa, abx377118
Methyl-Cpg-Binding Domain Protein 3 (MBD3) Antibody is a Rabbit polyclonal antibody for the detection of Human Methyl-Cpg-Binding Domain Protein 3 (MBD3).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody, Abbexa, abx113709
Methyl-Cpg Binding Domain Protein 3 Antibody is a Rabbit Polyclonal antibody against Methyl-Cpg Binding Domain Protein 3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody, Abbexa, abx036883
Rabbit Polyclonal against the MBD3 protein.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody, Abbexa, abx034839
Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing.
Host
Mouse
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody, Abbexa, abx325402
MBD3 Antibody is a Rabbit Polyclonal against MBD3.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB
Conjugation
Unconjugated
Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody, Abbexa, abx235035
MBD3 Antibody is a Rabbit Polyclonal against MBD3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC, IP
Conjugation
Unconjugated
Methyl-CpG Binding Domain Protein 3 (MBD3) Antibody, Abbexa, abx025698
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
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