Search results for Mothers Against Decapentaplegic Homolog 2 Phospho-Thr220 (SMAD2 pT220) Antibody
Mothers Against Decapentaplegic Homolog 2 Phospho-Thr220 (SMAD2 pT220) Antibody, Abbexa, abx032070
SMAD2 is a 58 kDa member of a family of proteins involved in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor-regulated Smad's, activin/TGF?receptor-regulated (Smad2 and 3) or BMP receptor regulated (Smad1, 5, and 8) ; the common partner, (Smad4) that functions via its interaction to the various Smad's; and the inhibitory Smad's, (Smad6 and Smad7). Smad2 consists of two highly conserved domains, the N terminal Mad homology (MH1) and the C-terminal Mad homology 2 (MH2) domains. The MH1 domain binds DNA and regulates nuclear import and transcription while the MH2 domain conserved among all the Smad's regulates Smad2 oligomerization and binding to cytoplasmic adaptors and transcription factors. Activated Smad2 associates with Smad4 and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. This translocation of Smad2 (as well as Smad3) into the nucleus is a central event in TGF beta signaling. Phosphorylation of threonine 8 in the calmodulin binding region of the MH1 domain by extracellular signal regulated kinase 1 (ERK 1) enhances Smad2 transcriptional activity, which is negatively regulated by calmodulin. The regulation of Smad2 phosphorylation on threonine 8 by ERK 1 and calmodulin is critical for Smad2 mediated signaling.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IF/ICC, DB
Conjugation
Unconjugated
Mothers Against Decapentaplegic Homolog 2 Phospho-Thr220 (SMAD2 pT220) Antibody, Abbexa, abx326721
SMAD2 (pT220) Antibody is a Rabbit Polyclonal against SMAD2 (pT220).
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC, IF/ICC
Conjugation
Unconjugated
Mothers Against Decapentaplegic Homolog 2 Phospho-Thr220 (SMAD2 pT220) Antibody, Abbexa, abx012486
Rabbit polyclonal antibody against Smad2 protein. Immunogen region is Internal. Specificity is as follows for the reactive species: H:T220, M:T220, R:T220.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IF/ICC
Conjugation
Unconjugated
Mothers Against Decapentaplegic Homolog 2 Phospho-Thr220 (SMAD2 pT220) Antibody, Abbexa, abx333437
SMAD2 (pT220) Antibody is a Rabbit Polyclonal against SMAD2 (pT220).
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
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