Search results for Natalizumab

Natalizumab Biosimilar – Anti-ITGA4, CD49d mAb – Research Grade, ProteoGenix, PX-TA1053

Description of Natalizumab Biosimilar - Anti-ITGA4, CD49d mAb - Research Grade General information on Anti-ITGA4/CD49d(Homo sapiens) (Natalizumab) Monoclonal Antibody Natalizumab is a humanized monoclonal antibody produced in murine myeloma cells of isotype IgG4k. Natalizumab contains a human framework region and a complementarity determining region of a murine antibody that binds to alpha 4-integrin. Natalizumab has been temporarily discontinued due to the risk of progressive multifocal leukoencephalopathy (PML).

Natalizumab, Abbexa, abx831019

Natalizumab is a monoclonal antibody biosimilar expressed in CHO cells, targeting ITGA4/CD49d, for use in laboratory research applications. This product is not suitable for use as medicines or in human, therapeutic or diagnostic applications. Natalizumab is a recombinant, humanized monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses.

Anti-Natalizumab ELISA Kit, ProteoGenix, KPTX356

Description of Anti-Natalizumab ELISA Kit Introduction The Anti-Natalizumab ELISA Kit is a highly sensitive and specific assay designed for the detection and quantification of human anti-natalizumab antibodies in various biological samples. Natalizumab is a monoclonal antibody that is used as a therapeutic agent for the treatment of multiple sclerosis and Crohn’s disease. However, due to its immunogenic nature, patients receiving natalizumab therapy may develop anti-natalizumab antibodies, which can lead to reduced efficacy and potential adverse effects. Therefore, the Anti-Natalizumab ELISA Kit is an essential tool for monitoring the immunogenicity of natalizumab and optimizing its therapeutic use. Structure of Anti-Natalizumab ELISA Kit The Anti-Natalizumab ELISA Kit is a sandwich enzyme-linked immunosorbent assay (ELISA) that detects antibodies against natalizumab and uses a horseradish peroxidase (HRP)-conjugated polyclonal antibody against human IgG as the detection antibody. The kit also includes a calibrator and controls to ensure the accuracy and precision of the assay. The assay is performed on a microplate coated with the capture antibody, and the HRP substrate is added to generate a colorimetric signal that is proportional to the amount of anti-natalizumab antibodies present in the sample. Activity of Anti-Natalizumab ELISA Kit The Anti-Natalizumab ELISA Kit has a high sensitivity and specificity, with a lower limit of detection of 0.1 ng/mL and a dynamic range of 0.5-100 ng/mL. The assay has been validated for various biological samples, including serum, plasma, and cerebrospinal fluid. It has also been shown to have excellent intra- and inter-assay precision, with coefficients of variation less than 10%. The assay has been compared to other methods, such as radioimmunoassay and flow cytometry, and has shown good correlation, indicating its reliability and accuracy. Application of Anti-Natalizumab ELISA Kit The Anti-Natalizumab ELISA Kit has several applications in both clinical and research settings. In clinical practice, it is used to monitor the immunogenicity of natalizumab in patients receiving therapy. High levels of anti-natalizumab antibodies can indicate a reduced response to treatment and may require a change in therapy. The assay can also be used to detect and monitor the development of neutralizing antibodies, which can completely block the therapeutic effect of natalizumab. In research, the Anti-Natalizumab ELISA Kit is a valuable tool for studying the pharmacokinetics and pharmacodynamics of natalizumab. It can be used to measure the levels of anti-natalizumab antibodies in different biological fluids and tissues, providing insights into the distribution and clearance of the drug. The assay can also be used to investigate the factors that influence the development of anti-natalizumab antibodies, such as patient demographics and treatment regimens. Conclusion In summary, the Anti-Natalizumab ELISA Kit is a highly sensitive and specific assay for the detection and quantification of anti-natalizumab antibodies. Its reliable performance and multiple applications make it an essential tool for monitoring the immunogenicity of natalizumab and optimizing its therapeutic use. With the increasing use of natalizumab in various autoimmune diseases, the Anti-Natalizumab ELISA Kit will continue to play a crucial role in ensuring the safe and effective use of this therapeutic agent.

Anti-Natalizumab Antibody (NAA84), AntibodySystem, RAC98801

Anti-Natalizumab Antibody (SAb2530), AntibodySystem, RAC98802

Natalizumab Biosimilar - Research Grade, ichor.bio, ICH4037

Detects human CD49d

Anti-Integrin alpha 4/CD49D antibody [Natalizumab] - Rabbit IgG (Chimeric), Abcam, AB275979

This rabbit monoclonal chimeric antibody was made using the variable domain sequences of the original human IgG4 format, for improved compatibility with existing reagents, assays and techniques.

Human Anti-Natalizumabantibody (Anti-Natalizumab) ELISA Kit, Abbexa, abx392520

Human Anti-Natalizumabantibody (Anti-Natalizumab) ELISA Kit is an ELISA Kit against Anti-Natalizumabantibody (Anti-Natalizumab).