Search results for Nibrin (NBN) Antibody
Nibrin (NBN) Antibody, Abbexa, abx016109
NBN Antibody is a Mouse Monoclonal against NBN.
Host
Mouse
Reactivity
Human, Rat
Applications
ELISA, WB, IHC, IF/ICC, FCM
Conjugation
Unconjugated
Nibrin (NBN) Antibody, Abbexa, abx224050
NBN Antibody is a Mouse Monoclonal against NBN.
Host
Mouse
Reactivity
Human
Applications
ELISA, WB, IHC, IF/ICC, FCM
Conjugation
Nibrin (NBN) Antibody, Abbexa, abx330172
NBN Antibody is a Rabbit Polyclonal against NBN.
Host
Rabbit
Reactivity
Human, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Nibrin (NBN) Antibody, Abbexa, abx026436
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IF/ICC, FCM
Conjugation
Unconjugated
Nibrin (NBN) Antibody, Abbexa, abx000860
NBN Antibody is a Rabbit Polyclonal antibody against NBN. NBN, also named as NBS, NBS1 and P95, is a component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. Defects in NBN are the cause of Nijmegen breakage syndrome (NBS). Defects in NBN are a cause of genetic susceptibility to breast cancer (BC). Defects in NBN may be associated with aplastic anemia. Defects in NBN might play a role in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). The antibody is specific to NBN.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Nibrin (NBN) Antibody, Abbexa, abx328648
NBN Antibody is a Rabbit Polyclonal against NBN.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Nibrin (NBN) Antibody, Abbexa, abx007234
NBN Antibody is a Rabbit Polyclonal Antibody against NBN.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IF/ICC
Conjugation
Unconjugated
Nibrin (NBN) Antibody, Abbexa, abx241401
NBN Antibody is a Rabbit Polyclonal against NBN.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC
Conjugation
Unconjugated
Nibrin (NBN) Antibody, Abbexa, abx376948
Nibrin (NBN) Antibody is a Rabbit polyclonal antibody for the detection of Human Nibrin (NBN).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Nibrin (NBN) Antibody, Abbexa, abx114103
Nibrin Antibody is a Rabbit Polyclonal antibody against Nibrin.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
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