Search results for Ocaratuzumab ELISA Kit
Ocaratuzumab ELISA Kit, Abbexa, abx395068
This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. Ocaratuzumab ELISA Kit is a quantitative ELISA kit for detection of Ocaratuzumab.Ocaratuzumab, previously known as AME-133v, is a humanized IgG1 type monoclonal antibody targeted at CD20 antigen, which is expressed on B-lymphocytes. Ocaratuzumab is a novel Fc-engineered monoclonal antibody designed by Applied Molecular Evolution in an attempt to induce effective antibody-dependent cell-mediated cytotoxicity (ADCC) at very low concentrations that may facilitate sub-cutaneous dosing. Libraries of antibody Fab fragment regions were generated with codon substituted variations of the antibody complementarity determining regions (CDRs) inserted into human antibody light and heavy chain germline frameworks. Then, the researchers expressed and selected mutants based on increased affinity for CD20. A variable region with increased binding activity for CD20 was selected and developed as ocaratuzumab. This drug is currently being developed by Mentrik Biotech and has been investigated in the trial for the treatment of cancer and autoimmune disorders. The pre-clinical trials of ocaratuzumab in follicular lymphoma was conducted in the United States (US) and Japan in phase I/II, and a Phase I trial was conducted in US rheumatoid arthritis patients. In addition, a phase III trial in relapsed follicular lymphoma patients is underway. Compared to rituximab, ocaratuzumab was shown to ocaratuzumab was shown to have 13 to 20 fold greater affinity for CD20 and 6 fold more potent ADCC in pre-clinical studies. The use of ocaratuzumab in other oncology and rheumatology indications has also been developed.
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Human
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Conjugation
Ocaratuzumab ELISA Kit, ProteoGenix, KPTX179
Description of Ocaratuzumab ELISA Kit Introduction to Ocaratuzumab ELISA Kit A Revolutionary Tool for Detecting and Studying Ocaratuzumab Antibody Ocaratuzumab is a monoclonal antibody that has gained significant attention in the field of cancer research. It is a humanized IgG1 kappa antibody that specifically targets the CD20 antigen, which is highly expressed on the surface of B cells. Ocaratuzumab has shown promising results in the treatment of B-cell malignancies, making it a potential therapeutic target for various types of cancer. Structure of Ocaratuzumab Antibody The structure of Ocaratuzumab antibody is composed of two heavy chains and two light chains, each containing variable and constant regions. The variable regions of the heavy and light chains are responsible for the antigen-binding site, while the constant regions provide stability and effector functions. Ocaratuzumab has a molecular weight of approximately 148 kDa and is produced through recombinant DNA technology, ensuring high purity and consistency in its structure. Activity of Ocaratuzumab Antibody Ocaratuzumab antibody exerts its activity through multiple mechanisms, making it an effective therapeutic agent. Its primary mode of action is by binding to the CD20 antigen on the surface of B cells, leading to their destruction through various pathways, including complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis. Ocaratuzumab has also been shown to inhibit B-cell proliferation and induce cell cycle arrest, making it a potential treatment option for B-cell malignancies. Ocaratuzumab ELISA Kit: A Powerful Tool for Detecting Ocaratuzumab Antibody The Ocaratuzumab ELISA Kit is a cutting-edge tool that enables the detection and quantification of Ocaratuzumab antibody in various biological samples. This kit utilizes the enzyme-linked immunosorbent assay (ELISA) technique, which is widely used in scientific research and diagnostic laboratories due to its sensitivity, specificity, and ease of use. The Ocaratuzumab ELISA Kit is designed to detect both free and bound Ocaratuzumab antibody, providing a comprehensive analysis of its levels in a given sample. Application of Ocaratuzumab ELISA Kit The Ocaratuzumab ELISA Kit has a wide range of applications in the field of cancer research, including: Biomarker Discovery: Ocaratuzumab ELISA Kit can be used to identify and validate Ocaratuzumab as a potential biomarker for various types of cancer. Its high sensitivity and specificity make it a valuable tool for biomarker discovery studies. Pharmacokinetic Studies: The Ocaratuzumab ELISA Kit can be used to measure the levels of Ocaratuzumab in blood or other biological samples, providing valuable information about its pharmacokinetics, including absorption, distribution, metabolism, and excretion. Therapeutic Monitoring: Monitoring Ocaratuzumab levels in patients undergoing treatment can help assess the efficacy of the therapy and guide treatment decisions. Research on Ocaratuzumab Mechanisms of Action: The Ocaratuzumab ELISA Kit can be used to study the interaction between Ocaratuzumab and its target antigen, CD20, and elucidate its mechanisms of action in different types of cancer. Conclusion The Ocaratuzumab ELISA Kit is a powerful tool for detecting and studying Ocaratuzumab antibody, a promising therapeutic target for various types of cancer. Its high sensitivity, specificity, and ease of use make it a valuable asset for
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