Search results for PRAK Antibody

PRAK Antibody, Abbexa, abx011374

PRAK (p38-regulated/activated kinase), also referred to as mitogen-activated protein kinase (MAPK)-activated protein kinase (MAPKAPK)-5, is an ubiquitously expressed serine/threonine kinase regulated by p38 alpha and p38 beta MAP kinases. Activated JNK, p38 gamma or p38 delta are unable to induce phosphorylation of PRAK in vitro. Phosphorylation of PRAK occurs in vivo in response to p38 activation by stress-related extracellular stimuli including UV light, oxidation and proinflammatory cytokines. Two other substrates for p38, MAPKAPK-2 and MAPKAPK-3/3pK, share approximately 45% sequence homology with PRAK including the phosphorylation motif recognized by p38, Lys-X-Thr-Pro. Activated PRAK has been shown to specifically phosphorylate HSP 27 in vitro, suggesting that the protein may play a role in stress-induced small heat shock protein phosphorylation in vivo.

PRAK antibody, Genetex, GTX107628

PRAK Antibody, Abbexa, abx033237

MAPKAPK5 is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites.

PRAK antibody [N1C1], Genetex, GTX105778

PRAK antibody [N3C3], Genetex, GTX107938

PRAK antibody [N1C2], Genetex, GTX108759

PRAK antibody [7H10B4], Genetex, GTX83275

Anti-PRAK Antibody (R4A71), AntibodySystem, RHN90701