Search results for Protein Inhibitor of Activated STAT2 (PIAS2) Antibody
Protein Inhibitor of Activated STAT2 (PIAS2) Antibody, Abbexa, abx322207
PIAS2 Antibody is a Rabbit Polyclonal against PIAS2.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB
Conjugation
Unconjugated
Protein Inhibitor of Activated STAT2 (PIAS2) Antibody, Abbexa, abx329869
PIAS2 Antibody is a Rabbit Polyclonal against PIAS2.
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Applications
ELISA, WB
Conjugation
Unconjugated
Protein Inhibitor of Activated STAT2 (PIAS2) Antibody, Abbexa, abx004324
PIAS2 Antibody is a Rabbit Polyclonal antibody against PIAS2. This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Protein Inhibitor of Activated STAT2 (PIAS2) Antibody, Abbexa, abx026841
PIASX functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. PIASX binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
Protein Inhibitor of Activated STAT2 (PIAS2) Antibody, Abbexa, abx013224
Rabbit polyclonal antibody against PIAS2 protein. Immunogen region is N-terminal.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
Protein Inhibitor of Activated STAT2 (PIAS2) Antibody, Abbexa, abx146419
PIAS2 Antibody is a Rabbit Polyclonal against PIAS2.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Protein Inhibitor of Activated STAT2 (PIAS2) Antibody, Abbexa, abx236429
PIAS2 Antibody is a Rabbit Polyclonal against PIAS2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
Protein Inhibitor of Activated STAT2 (PIAS2) Antibody, Abbexa, abx431432
PIAS2 Antibody is a Goat Polyclonal antibody against PIAS2.
Host
Goat
Reactivity
Human
Applications
P-ELISA, WB
Conjugation
Unconjugated
Protein Inhibitor of Activated STAT2 (PIAS2) Antibody, Abbexa, abx026846
PIASX functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. PIASX binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. This antibody is directed against an epitope specific to PIAS2-alpha. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Protein Inhibitor of Activated STAT2 (PIAS2) Antibody, Abbexa, abx431431
PIAS2 Antibody is a Goat Polyclonal antibody against PIAS2.
Host
Goat
Reactivity
Human
Applications
P-ELISA, IHC
Conjugation
Unconjugated
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