Search results for Pyruvate Dehydrogenase Complex Component X (PDHX) Antibody
Pyruvate Dehydrogenase Complex Component X (PDHX) Antibody, Abbexa, abx031493
PDX1, located in the mitochondrial matrix, is required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. Eukaryotic pyruvate dehydrogenase complexes are organized about a core consisting of the oligomeric dihydrolipoamide acetyl-transferase, around which are arranged multiple copies of pyruvate dehydrogenase, dihydrolipoamide dehydrogenase and protein X bound by noncovalent bonds. Defects in PDHX are a cause of lacticacidemia. PDX1 belongs to the 2-oxoacid dehydrogenase family and contains 1 lipoyl-binding domain.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Pyruvate Dehydrogenase Complex Component X (PDHX) Antibody, Abbexa, abx236271
PDHX Antibody is a Rabbit Polyclonal against PDHX.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IP
Conjugation
Unconjugated
Pyruvate Dehydrogenase Complex, Component X (PDHX) Antibody, Abbexa, abx114942
Pyruvate Dehydrogenase Complex, Component X Antibody is a Rabbit Polyclonal antibody against Pyruvate Dehydrogenase Complex, Component X.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Pyruvate Dehydrogenase Complex Component X (PDHX) Antibody, Abbexa, abx031492
PDX1, located in the mitochondrial matrix, is required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. Eukaryotic pyruvate dehydrogenase complexes are organized about a core consisting of the oligomeric dihydrolipoamide acetyl-transferase, around which are arranged multiple copies of pyruvate dehydrogenase, dihydrolipoamide dehydrogenase and protein X bound by noncovalent bonds. Defects in PDHX are a cause of lacticacidemia. PDX1 belongs to the 2-oxoacid dehydrogenase family and contains 1 lipoyl-binding domain.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Pyruvate Dehydrogenase Complex Component X (PDHX) Antibody, Abbexa, abx321688
PDHX Antibody is a Rabbit Polyclonal against PDHX.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Pyruvate Dehydrogenase Complex Component X (PDHX) Antibody, Abbexa, abx004919
PDHX Antibody is a Rabbit Polyclonal antibody against PDHX. The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IP
Conjugation
Unconjugated
Pyruvate Dehydrogenase Complex Component X (PDHX) Antibody, Abbexa, abx129031
Pyruvate Dehydrogenase Complex Component X Antibody is a Rabbit Polyclonal against Pyruvate Dehydrogenase Complex Component X.
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Pyruvate Dehydrogenase Complex Component X (PDHX) Antibody, Abbexa, abx129794
Pyruvate Dehydrogenase Complex Component X Antibody is a Rabbit Polyclonal against Pyruvate Dehydrogenase Complex Component X.
Host
Rabbit
Reactivity
Mouse
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Pyruvate Dehydrogenase Complex Component X (PDHX) Antibody, Abbexa, abx137680
Pyruvate Dehydrogenase Complex Component X (PDHX) Antibody is a Mouse Monoclonal antibody against Pyruvate Dehydrogenase Complex Component X (PDHX).
Host
Mouse
Reactivity
Human
Applications
Conjugation
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