Search results for Recombination Activating Gene 2 (RAG2) Antibody
Recombination Activating Gene 2 (RAG2) Antibody, Abbexa, abx004301
RAG2 Antibody is a Rabbit Polyclonal antibody against RAG2. This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
Host
Rabbit
Reactivity
Mouse
Applications
WB
Conjugation
Unconjugated
Recombination Activating Gene 2 (RAG2) Antibody, Abbexa, abx026817
This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. This gene encodes a protein that is involved in the initiation of V (D) J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC, FCM
Conjugation
Unconjugated
Recombination Activating Gene 2 (RAG2) Antibody, Abbexa, abx122999
RAG2 Antibody is a Rabbit Polyclonal against RAG2.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Recombination Activating Gene 2 (RAG2) Antibody, Abbexa, abx237089
RAG2 Antibody is a Rabbit Polyclonal against RAG2.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC, IF/ICC, FCM, IP
Conjugation
Unconjugated
Recombination Activating Gene 2 (RAG2) Antibody, Abbexa, abx012073
This gene encodes a protein that is involved in the initiation of V (D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
Host
Mouse
Reactivity
Human
Applications
ELISA
Conjugation
Unconjugated
Please provide the required information below so that we can quickly source your products.