Search results for Serine, Threonine-Protein Kinase Nek2 (NEK2) Antibody
Serine, Threonine-Protein Kinase Nek2 (NEK2) Antibody, Abbexa, abx033852
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Serine, Threonine-Protein Kinase Nek2 (NEK2) Antibody, Abbexa, abx235651
NEK2 Antibody is a Rabbit Polyclonal against NEK2.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Serine, Threonine-Protein Kinase Nek2 (NEK2) Antibody, Abbexa, abx213477
NEK2 Antibody is a Rabbit Polyclonal against NEK2.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB
Conjugation
Unconjugated
Serine, Threonine-Protein Kinase Nek2 (NEK2) Antibody, Abbexa, abx235652
NEK2 Antibody is a Rabbit Polyclonal against NEK2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Serine, Threonine-Protein Kinase Nek2 (NEK2) Antibody, Abbexa, abx146251
NEK2 Antibody is a Rabbit Polyclonal against NEK2.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Serine, Threonine-Protein Kinase Nek2 (NEK2) Antibody, Abbexa, abx004096
NEK2 Antibody is a Rabbit Polyclonal antibody against NEK2. This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene.
Host
Rabbit
Reactivity
Human, Rat
Applications
WB, IHC
Conjugation
Unconjugated
Serine, Threonine-Protein Kinase Nek2 (NEK2) Antibody, Abbexa, abx025140
NEK2 is closely related in its catalytic domain to the serine/threonine protein kinase NIMA of Aspergillus nidulans which is required for entry into mitosis and may function in parallel to the universal mitotic inducer p34cdc2. Like NIMA, the Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2. These observations demonstrate that NEK2 resembles Aspergillus NIMA, both in its catalytic domain, and cell cycle-dependent expression. Recombinant NEK2 is active as a serine/threonine-specific protein kinase and may undergo autophosphorylation. Both human NEK2 and fungal NIMA phosphorylate a similar, but not identical, set of proteins and synthetic peptides. NEK2 is shown to be expressed most abundantly in adult testis and there is increasing evidence that NEK2 is abnormally expressed in a wide variety of human cancers. This antibody is specific to isoform 2 of NEK2.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Serine, Threonine-Protein Kinase Nek2 (NEK2) Antibody, Abbexa, abx320236
NEK2 Antibody is a Rabbit Polyclonal against NEK2.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
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