Search results for Sialic Acid-Binding Ig-Like Lectin 5 (SIGLEC5) Antibody
Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Antibody, Abbexa, abx339247
SIGLEC5 Antibody is a Rabbit Polyclonal against SIGLEC5.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
Sialic Acid-Binding Ig-Like Lectin 5 (SIGLEC5) Antibody, Abbexa, abx376821
Sialic Acid-Binding Ig-Like Lectin 5 (SIGLEC5) Antibody is a Rabbit polyclonal antibody for the detection of Human Sialic Acid-Binding Ig-Like Lectin 5 (SIGLEC5).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Antibody, Abbexa, abx028681
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIM). SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. Sequence analysis predicted that the 697-amino acid SIGLEC10 protein contains a signal peptide, an N-terminal V-set Ig-like domain and four C2-set Ig-like domains, five potential N-linked glycosylation sites, a transmembrane region, and a 126-residue cytoplasmic tail with 3 putative ITIMs. Northern blot analysis detected a major 3.0-kb SIGLEC10 transcript, with highest levels in spleen, lymph node, blood leukocytes, and appendix. Little or no expression was observed in pancreas, thyroid, and testis. Flow cytometric analysis demonstrated eosinophil-specific expression of SIGLEC10, but at a lower level than that of SIGLEC8. Expression was also detected on monocytes and a CD16-positive/CD56-negative natural killer-like lymphocyte population. After sialidase treatment, which is necessary for unmasking the sialic acid-binding site on SIGLECs interacting with cell surface sialic acids, cells expressing SIGLEC10 bound to red blood cells. Immunoprecipitation analysis indicated expression of a 100 to 120-kD monomeric protein, higher than the predicted molecular mass, suggesting that SIGLEC10 is glycosylated.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB
Conjugation
Unconjugated
Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Antibody, Abbexa, abx003149
SIGLEC5 Antibody is a Rabbit Polyclonal antibody against SIGLEC5. This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
Host
Rabbit
Reactivity
Mouse
Applications
ELISA, WB
Conjugation
Unconjugated
Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Antibody, Abbexa, abx323780
SIGLEC5 Antibody is a Rabbit Polyclonal against SIGLEC5.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Antibody, Abbexa, abx104092
Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5).
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Antibody, Abbexa, abx028965
The sialic acid-binding immunoglobulin-like lectins (SIGLECs), such as SIGLEC5, are a subgroup of the immunoglobulin (Ig) superfamily that mediate protein-carbohydrate interactions. They specifically interact with sialic acids in glycoproteins and glycolipids, with each SIGLEC having a particular preference for both the nature of the sialic acid and its glycosidic linkage to adjacent sugars. SIGLECs have similar structures, including extracellular Ig-like domains composed of an N-terminal V-set domain followed by varying numbers of C2-set domains. It appears that all SIGLECs have an unusual arrangement of conserved cysteine residues in the V-set and adjacent C2-set domains. Most SIGLECs are expressed uniquely within the hematopoietic system (Cornish et al., 1998 [PubMed 9731071]).
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Antibody, Abbexa, abx104093
Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5).
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Antibody, Abbexa, abx140508
Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Antibody is a Mouse Monoclonal against Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5).
Host
Mouse
Reactivity
Human, Monkey
Applications
ELISA, IHC, IF/ICC, FCM, IP
Conjugation
Unconjugated
Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Antibody, Abbexa, abx104094
Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5).
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
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