Search results for TSC2 (pS1096) Antibody
TSC2 (pS1096) Antibody, Abbexa, abx032287
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.
Host
Rabbit
Reactivity
Human
Applications
ELISA, DB
Conjugation
Unconjugated
Mouse TSC2 (pS1096) Antibody, Abbexa, abx032229
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity).
Host
Rabbit
Reactivity
Mouse
Applications
ELISA, DB
Conjugation
Unconjugated
Please provide the required information below so that we can quickly source your products.