Search results for Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody
Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody, Abbexa, abx117043
TICAM1 Antibody is a Rabbit Polyclonal antibody against TICAM1. Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responsesTLRs recognize conserved motifs found in various pathogens and mediate defense responsesTriggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genesThe TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domainUpon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule)This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKKActivation of IKK leads to the degradation of IκB that normally maintains NF-κB inactivity by sequestering it in the cytoplasmTRIF (also termed TICAM-1) is a TIR-domain adaptor protein described to activate NF-κB, IRF3 and trigger IFN-β productionStudies using dominant negative forms of TRIF and siRNA targeting TRIF show that TRIF functions downstream of both TLR3 and TLR4 in response to dsRNA and LPS respectivelyTRIF recruits TRAF6-TAK1-TAB2 to the receptor complex which leads to NF-κB activationIn addition, TRIF can trigger signaling of that lead to the induction of apoptosis.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody, Abbexa, abx129792
Toll Like Receptor Adaptor Molecule 1 Antibody is a Rabbit Polyclonal against Toll Like Receptor Adaptor Molecule 1.
Host
Rabbit
Reactivity
Mouse
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody, Abbexa, abx129122
Toll Like Receptor Adaptor Molecule 1 Antibody is a Rabbit Polyclonal against Toll Like Receptor Adaptor Molecule 1.
Host
Rabbit
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody, Abbexa, abx325000
TICAM1 Antibody is a Rabbit Polyclonal against TICAM1.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody, Abbexa, abx001069
TICAM1 Antibody is a Rabbit Polyclonal antibody against TICAM1. This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB
Conjugation
Unconjugated
Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody, Abbexa, abx174847
This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody is a Mouse Monoclonal antibody against Toll Like Receptor Adaptor Molecule 1 (TICAM1).
Host
Mouse
Reactivity
Human
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody, Abbexa, abx034891
Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB
Conjugation
Unconjugated
Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody, Abbexa, abx219127
Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody is a Rabbit Polyclonal antibody for the detection of TRIF.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
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