Search results for Tyrosine-protein kinase Lck
Tyrosine-Protein Kinase Lck (LCK) Antibody, Abbexa, abx159593
LCK Antibody is a Mouse Monoclonal against LCK.
Host
Mouse
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Proto-Oncogene Tyrosine-Protein Kinase LCK (LCK) Antibody, Abbexa, abx328129
LCK Antibody is a Rabbit Polyclonal against LCK.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IF/ICC
Conjugation
Unconjugated
Proto-Oncogene Tyrosine-Protein Kinase LCK (LCK) Antibody, Abbexa, abx234725
LCK Antibody is a Rabbit Polyclonal against LCK.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IP
Conjugation
Unconjugated
Proto-Oncogene Tyrosine-Protein Kinase LCK (LCK) Antibody, Abbexa, abx113550
Lymphocyte-Specific Protein Tyrosine Kinase Antibody is a Rabbit Polyclonal antibody against Lymphocyte-Specific Protein Tyrosine Kinase.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Proto-Oncogene Tyrosine-Protein Kinase LCK (LCK) Antibody, Abbexa, abx033638
LSK, which belongs to the SRC subfamily of Tyr protein kinases, may participate in antigen-induced T-cell activation. It binds to phosphatidylinositol 3'-kinase (PI3K) from T lymphocytes through its SH3 domain and to the tyrosine phosphorylated form of KHDRBS1/p70 through its SH2 domain. LSK is bound to the cytoplasmic domain of either CD4 or CD8. This protein is involved in leukemias by a chromosomal translocation t (1;7) (p34;q34) which involves LCK and T-cell receptor beta chain (TCRB) genes.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC, IF/ICC, FCM
Conjugation
Unconjugated
Proto-Oncogene Tyrosine-Protein Kinase LCK (LCK) Antibody, Abbexa, abx328157
LCK Antibody is a Rabbit Polyclonal against LCK.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IF/ICC
Conjugation
Unconjugated
Proto-Oncogene Tyrosine-Protein Kinase LCK (LCK) Antibody, Abbexa, abx329603
LCK Antibody is a Rabbit Polyclonal against LCK.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Proto-Oncogene Tyrosine-Protein Kinase LCK (LCK) Antibody, Abbexa, abx031732
LCK is a member of the Src family of protein tyrosine kinases (PTKs). This protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC, FCM
Conjugation
Unconjugated
Proto-Oncogene Tyrosine-Protein Kinase LCK (LCK) Antibody, Abbexa, abx012318
Tyrosine kinase that plays an essential role for the selection and maturation of developing t-cell in the thymus and in mature t-cell function. is constitutively associated with the cytoplasmic portions of the cd4 and cd8 surface receptors and plays a key role in t-cell antigen receptor (tcr)-linked signal transduction pathways. association of the tcr with a peptide antigen-bound mhc complex facilitates the interaction of cd4 and cd8 with mhc class ii and class i molecules, respectively, and thereby recruits the associated lck to the vicinity of the tcr/cd3 complex. lck then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (itams) in the cytoplasmic tails of the tcr gamma chains and cd3 subunits, initiating the tcr/cd3 signaling pathway. in addition, contributes to signaling by other receptor molecules. associates directly with the cytoplasmic tail of cd2, and upon engagement of the cd2 molecule, lck undergoes hyperphosphorylation and activation. also plays a role in the il2 receptor-linked signaling pathway that controls t-cell proliferative response. binding of il2 to its receptor results in increased activity of lck. is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-tcr and mature alpha beta tcr.
Host
Mouse
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Proto-Oncogene Tyrosine-Protein Kinase LCK (LCK) Antibody, Abbexa, abx234726
LCK Antibody is a Rabbit Polyclonal against LCK.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB
Conjugation
Unconjugated
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