Search results for Ubiquilin 1 (UBQLN1) Antibody
Ubiquilin 1 (UBQLN1) Antibody, Abbexa, abx031567
PLIC1 is an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Ubiquilin-1 (UBQLN1) Antibody, Abbexa, abx038075
Rabbit Polyclonal against the UBQLN1 protein.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Ubiquilin-1 (UBQLN1) Antibody, Abbexa, abx241328
UBQLN1 Antibody is a Rabbit Polyclonal against UBQLN1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC
Conjugation
Unconjugated
Ubiquilin 1 (UBQLN1) Antibody, Abbexa, abx239196
Ubiquilin 1 Antibody is a Rabbit Polyclonal against Ubiquilin 1.
Host
Rabbit
Reactivity
Human, Rat
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Ubiquilin 1 (UBQLN1) Antibody, Abbexa, abx025096
Ubiquilin 1 (UBQLN1), also known as DA41, was isolated from an adult rat lung cDNA library, and encodes a cellular protein that associates with DAN.1 DAN expression is reduced in rat fibroblast 3Y1 cells transformed with mouse sarcoma virus and in rodent fibroblasts transformed with a variety of oncogenes. The DAN-DA41 interaction is mediated through the N-terminal domain and a cysteine-knot region of DAN. Human DA41 encodes a 589-amino acid protein with 86% amino acid sequence identity with rat protein.2 DA41 expression is regulated in a cell cycle-dependent manner. PLIC1 and PLIC2 (UBQLN2) are homologs of the mouse Plics (proteins linking integrin-associated protein (IAP) and cytoskeleton) and the yeast Dsk2 protein. PLIC1, also called UBQLN1, shares 72% amino acid identity with PLIC2, 3 Two motifs are conserved in the mammalian PLICs and yeast Dsk2, an N-terminal ubiquitin-like (UBL) domain and a C-terminal ubiquitin-associated (UBA) domain. Unlike ubiquitin, the UBL domain of the PLICs does not have a diglycine motif in its C terminus. The UBA domain is present in multiple enzyme classes of the ubiquitination machinery. Human PLICs associate with both proteasomes and ubiquitin ligases in large complexes. Overexpression of PLICs impairs the in vivo degradation of 2 unrelated ubiquitin-dependent proteasome substrates, p53 and I-kappa-B-alpha (NFKBIA), but not a ubiquitin-independent substrate. PLICs may link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. The DA41 gene maps to chromosome 9q21.2-q21.3, a position overlapping a candidate tumor suppressor locus for bladder cancer.2.
Host
Rabbit
Reactivity
Human, Mouse
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Ubiquilin-1 (UBQLN1) Antibody, Abbexa, abx214079
UBQLN1 Antibody is a Rabbit Polyclonal against UBQLN1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Ubiquilin-1 (UBQLN1) Antibody, Abbexa, abx318797
UBQLN1 Antibody is a Rabbit Polyclonal against UBQLN1.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC, IF/ICC
Conjugation
Unconjugated
Ubiquilin-1 (UBQLN1) Antibody (HRP), Abbexa, abx316666
UBQLN1 Antibody (HRP) is a Rabbit Polyclonal against UBQLN1 conjugated to HRP.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
HRP
Ubiquilin-1 (UBQLN1) Antibody (Biotin), Abbexa, abx316668
UBQLN1 Antibody (Biotin) is a Rabbit Polyclonal against UBQLN1 conjugated to Biotin.
Host
Rabbit
Reactivity
Human
Applications
ELISA
Conjugation
Biotin
Ubiquilin-1 (UBQLN1) Antibody (FITC), Abbexa, abx316667
UBQLN1 Antibody (FITC) is a Rabbit Polyclonal against UBQLN1 conjugated to FITC.
Host
Rabbit
Reactivity
Human
Applications
Conjugation
FITC
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