Search results for Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) Antibody
Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) Antibody, Abbexa, abx031540
USP2, an ubiquitin-specific protease, is selectively up regulated in bone by the osteotropic agents PTH, PTHrP and PGE2 and possibly via the PKA/cAMP pathway. It is also thought to play a role in the recycling of ubiquitin by hydrolysis of branched poly-ubiquitin from linear poly-ubiquitin chains, production of free ubiquitin from linear poly-ubiquitin chains and from certain ribosomal ubiquitin fusion proteins.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) Antibody, Abbexa, abx031539
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs), 1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
Host
Rabbit
Reactivity
Human
Applications
ELISA, WB
Conjugation
Unconjugated
Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) Antibody, Abbexa, abx239316
USP2 Antibody is a Rabbit Polyclonal against USP2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) Antibody, Abbexa, abx405667
This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. Mouse Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) Antibody is a Rabbit polyclonal against Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2).
Host
Rabbit
Reactivity
Mouse
Applications
WB, IHC, IF/ICC
Conjugation
Unconjugated
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Antibody, Abbexa, abx213805
USP2 Antibody is a Rabbit Polyclonal against USP2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC
Conjugation
Unconjugated
Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) Antibody, Abbexa, abx318706
USP2 Antibody is a Rabbit Polyclonal against USP2.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IF/ICC
Conjugation
Unconjugated
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Antibody, Abbexa, abx241618
USP2 Antibody is a Rabbit Polyclonal against USP2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, IHC
Conjugation
Unconjugated
Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) Antibody, Abbexa, abx239864
Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) Antibody is a Rabbit Polyclonal antibody for the detection of USP2. Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).
Host
Rabbit
Reactivity
Human, Mouse, Rat
Applications
ELISA, WB, IHC, IF/ICC
Conjugation
Unconjugated
Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) Antibody, Abbexa, abx321351
USP2 Antibody is a Rabbit Polyclonal against USP2.
Host
Rabbit
Reactivity
Human
Applications
ELISA, IHC
Conjugation
Unconjugated
Ubiquitin Carboxyl-Terminal Hydrolase 2 (USP2) Antibody, Abbexa, abx031538
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs), 1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
Host
Rabbit
Reactivity
Human, Rat
Applications
ELISA, WB, IHC
Conjugation
Unconjugated
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