Search results for Wiskott-Aldrich Syndrome (WAS) Antibody

Wiskott-Aldrich Syndrome (WAS) Antibody, Abbexa, abx000931

WAS Antibody is a Rabbit Polyclonal antibody against WAS. Wiskott-Aldrich syndrome proteins (WASPs) mediate actin dynamics by activating the Arp2/3 actin nucleation complex in response to activated Rho family GTPases. In mammals, five WASP family members have been described. Hematopoietic WASP and ubiquitously expressed N-WASP are autoinhibited in unstimulated cells. Upon stimulation they are activated by cdc42, which relieves the autoinhibition in conjunction with phosphatidyl inositol 4,5-bisphosphate. Three WAVE (Wasf, SCAR) family proteins are similar in sequence to WASP and N-WASP but lack the WASP/N-WASP autoinhibition domains and are indirectly activated by Rac (reviewed in 1). Both WASP and WAVE functions appear to be essential, as knockout of either N-WASP or Scar-2 in mice results in cardiac and neuronal defects and embryonic lethality (2,3). Loss of WASP results in immune system defects and fewer immune cells (4). WAVE-2 (WASF2) is widely distributed, while WAVE-1 and WAVE-3 are strongly expressed in brain (5). WAVE-3 may act as a tumor suppressor in neuroblastoma, a childhood disease of the sympathetic nervous system (6). Increased expression of WAVE-3 is seen in breast cancer, and studies in breast adenocarcinoma cells indicate that WAVE-3 regulates breast cancer progression, invasion and metastasis through the p38 mitogen-activated protein kinase (MAPK) pathway (7,8).

Wiskott-Aldrich Syndrome (WAS) Antibody, Abbexa, abx326005

WAS Antibody is a Rabbit Polyclonal against WAS.

Wiskott-Aldrich Syndrome (WAS) Antibody, Abbexa, abx116677

WAS Antibody is a Rabbit Polyclonal antibody against WAS.

Wiskott-Aldrich Syndrome (WAS) Antibody, Abbexa, abx338549

WAS Antibody is a Rabbit Polyclonal against WAS.

Wiskott-Aldrich Syndrome (WAS) Antibody, Abbexa, abx031070

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

Wiskott-Aldrich Syndrome (WAS) Antibody (FITC), Abbexa, abx338315

WAS Antibody (FITC) is a Rabbit Polyclonal against WAS.

Wiskott-Aldrich Syndrome (WAS) Antibody (HRP), Abbexa, abx338314

WAS Antibody (HRP) is a Rabbit Polyclonal against WAS.

Wiskott-Aldrich Syndrome (WAS) Antibody (Biotin), Abbexa, abx338316

WAS Antibody (Biotin) is a Rabbit Polyclonal against WAS.

Anti-WASP/Wiskott-Aldrich syndrome protein antibody, Abcam, AB180816

Anti-WASP/Wiskott-Aldrich syndrome protein antibody, Abcam, AB233216