Search results for abx000636

Midkine (MDK) Antibody, Abbexa, abx000636

MDK Antibody is a Rabbit Polyclonal antibody against MDK. Midkine, or MDK, is a heparin-binding molecule involved in the regulation of growth and differentiation during embryogenesis. MDK expression is tightly regulated during embryonic development by steroid receptors of the retinoic acid superfamily. The mature human MDK protein is 118 amino acids in length and contains five intrachain disulfide bonds. MDK is a non-glycosylated protein that shows greater than 87% identity between human and mouse. The carboxy-terminus of MDK contains the principle heparin-binding site and the molecule’s neurite-promoting sequences; both the amino- and carboxy-terminal sequences are required for the molecule’s neurotrophic properties. An association between overexpression of MDK and colon adenocarcinoma has been shown in families suffering from familial polyposis. In addition, MDK functions to enhance the activity of plasminogen activator (PA).