Search results for abx012306

Tyrosine Kinase 2 (TYK2) Antibody, Abbexa, abx012306

TYK2 (tyrosine kinase 2),with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. TYK2 is activated by a variety of cytokines: IFN alpha, IFN beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN gamma production by Th1-type CD4 cells. TYK2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. TYK2 is also an important regulator of lymphoid tumor surveillance.