Search results for abx015830

CREB Regulated Transcription Coactivator 3 (CRTC3) Antibody, Abbexa, abx015830

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation.Enhances the interaction of CREB1 with TAF4.Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR.Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells.Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).Tissue specificity: Predominantly expressed in B and T lymphocytes.Highest levels in lung.Also expressed in brain, colon, heart, kidney, ovary, and prostate.Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.