Search results for abx015941

Nuclear Factor NF-Kappa-B P105 Subunit (NFKB1) Antibody, Abbexa, abx015941

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein.The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex.NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products.Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions.Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth.Two transcript variants encoding different isoforms have been found for this gene.