Search results for abx016034

KSHV ORF45 Antibody, Abbexa, abx016034

Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma- (2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease.The genome of KSHV is 165-170 kb and contains at least 88 open reading frames.ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells.Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7.In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN.Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions.