Search results for abx110194

Ryanodine Receptor 1, Skeletal (RYR1) Antibody, Abbexa, abx110194

RYR1 is a calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of t-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm. RYR1 can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain. It is required for normal embryonic development of muscle fibers, skeletal muscle, normal heart morphogenesis, skin development and ossification.