Search results for abx127125

SPRY Domain-Containing SOCS Box Protein 1 (SPSB1) Antibody, Abbexa, abx127125

SPRY Domain-Containing SOCS Box Protein 1 (SPSB1) Antibody is a Rabbit Polyclonal against SPRY Domain-Containing SOCS Box Protein 1 (SPSB1). SPSB1 is a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein E3 ubiquitin-protein ligase complex) that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It also negatively regulates nitric oxide production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5.