Search results for abx148388

Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha (ATF6) Antibody, Abbexa, abx148388

Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha (ATF6) Antibody is a Rabbit Polyclonal antibody for the detection of ATF6. Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N (9) -CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.