Search results for abx229990

SARS-CoV-2 Non-Structural Protein 3 Antibody, Abbexa, abx229990

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) NSP3 Antibody is a Rabbit Polyclonal antibody for the detection of SARS-CoV-2 NSP3. Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.