Search results for abx230209

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody, Abbexa, abx230209

Advanced Glycosylation End Product Specific Receptor (AGER) Antibody is a Rabbit polyclonal against Advanced Glycosylation End Product Specific Receptor (AGER). AGER mediates interactions of advanced glycosylation end products (AGE), non-enzymatically glycosylated proteins that accumulate in vascular tissue in aging and at an accelerated rate in diabetes. AGER is a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. It interacts with S100A12 on endothelium, mononuclear phagocytes and lymphocytes, triggers cellular activation and generates important proinflammatory mediators. It is a receptor for amyloid beta peptide and facilitates its translocation across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase(MAPK), has the capacity to drive a transport system delivering ABPP asa complex with RAGE to the intraneuronal space. AGER also binds oligonucleotides.