Search results for abx239900

Sequestosome 1 (SQSTM1) Antibody, Abbexa, abx239900

Sequestosome 1 (P62/SQSTM1) Antibody is a Mouse Monoclonal antibody for the detection of P62/SQSTM1. This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.