Search results for abx395021

Gevokizumab ELISA Kit, Abbexa, abx395021

Gevokizumab ELISA Kit is a quantitative ELISA kit for detection of Gevokizumab.Gevokizumab (XOMA-052) was developed by XOMA Ltd., USA and represents a humanized IgG2 kappa antibody. XOMA-052 binds to IL-1β with high affinity leading to reduced binding affinity of the cytokine to its signaling receptor. Since gevokizumab does not influence the affinity of IL-1β for its decoy and soluble inhibitory receptors the endogenous regulatory mechanisms involving the clearance and inhibitory receptors also contribute to the effect of the antibody [6]. In August 2012 the FDA granted orphan drug status to gevokizumab for the treatment of noninfectious intermediate uveitis, posterior uveitis, panuveitis, and chronic noninfectious anterior uveitis. A single intravenous injection of the substance was also shown to lead to complete resolution of intraocular inflammation in Behçet’s uveitis.